Pathology

CYTOLOGY- TYPES OF CELLS

TYPES OF CELLS SEEN ON CERVICAL CYTOLOGY

Normal Findings

Basal Cells
Basal cells are small (10 u) in size and possess blue cytoplasm. Nuclei are large about 8 u in size. N:C ratio is high. Basal cells generally do not shed, but may be seen in smears obtained from vigorous endocervical brushing and present as sheets of small endocervical cells with uniform dense nuclei. Basal cell hyperplasia may occur in early metaplasia

Parabasal Cells
Parabasal cells are round cells, 10-15 u in size and show cyanophilic cytoplasm (Fig. 16.7), with centrally located vesicular nuclei. Cytoplasm is more abundant than basal cells.

Intermediate Cells
Intermediate cells are large (15-40 u), polyhedral in shape, and possess abundant cytoplasm and central vesicular nuclei. Cytoplasm is amphophilic to light basophilic in col or (Fig. 16.8).

Navicular Cells
Navicular cells are a variant of intermediate cells. Cells become oval or boat-shaped and show folding of cytoplasm (Fig. 16.9). Glycogen deposits stain yellow. These are seen is pregnancy and early menopause,however, are not diagnostic of pregnancy. Thus it is importance to mention the age of the woman and clinical history of amenorrhoea, if present.

Superficial Cells
Superficial cells are large (40-60 u), polyhedral cells with abundant eosinophilic cytoplasm and small dense pyknotic nuclei, with small perinuclear halo in many cells (Fig. 16.10). In abnormal conditions, these cells are keratinized and are seen as anucleate, polygonal, pink, transparent cells.